Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection.

Title:

Dataset

identifier:	1503038
description:	epitope description:SADNNNSEYSWT antigen name:Capsid protein VP1 host organism:Mus musculus BALB/c antibody name:C37-B
aggregation:	instance of dataset
availability:	available
primaryPublications:	10982375

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006090
landingPage:	http://www.iedb.org/assay/1503038

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2000

Dimension

study type:	b cell assays
subject species:	Adeno-associated virus - 2

Person

fullName:	C E Wobus B Hü gle-Dö rr A Girod G Petersen M Hallek J A Kleinschmidt

Data Type

method:	antigen inhibition

Study

name:	Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection.
description:	The epitope competed with AAV-2 for binding the epitope-specific mAb, which recognizes a conformational epitope. The authors conclude that the epitope sequence is a major part of the C37-B epitope with a minor contribution from region 601-610. Asparagines at positions 4 and 5 were shown to be important for antibody binding by mutation analysis.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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