Analysis of the epitopes on staphylococcal enterotoxin A responsible for emetic activity. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Analysis of the epitopes on staphylococcal enterotoxin A responsible for emetic activity.

Dataset

identifier:	1504194
description:	epitope description:EEKKVPINLWLDGKQNTVPL antigen name:Enterotoxin type A host organism:Oryctolagus cuniculus albino
aggregation:	instance of dataset
availability:	available
primaryPublications:	11307922

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013041
landingPage:	http://www.iedb.org/assay/1504194

Publication

type:	Literature
publicationVenue:	J Vet Med Sci
dates:	2001

Dimension

study type:	b cell assays
subject species:	Staphylococcus aureus

Person

fullName:	D L Hu K Omoe M H Saleh K Ono S Sugii A Nakane K Shinagawa

Data Type

method:	biological activity

Study

name:	Analysis of the epitopes on staphylococcal enterotoxin A responsible for emetic activity.
description:	The epitope sequence is published in the cited reference Huang et al., J Biol Chem. 1987 May 25 262(15):7006-13. [PMID: 3584106 ]. The ability of anti-peptide antibodies to neutralize SEA-induced emesis in Suncus murinus was determined by incubating the antibodies with SEA, and then injecting the mixture intraperitoneally. A positive response was based on inhibition of emesis in individual animals. Mixtures of antibodies against select epitopes identified in this study were found to give complete neutralization of emesis.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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