Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations.

Dataset

identifier:	1508215
description:	epitope description:TKDTNNNLCG + D-aa(C9) host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	12729743

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1010393
landingPage:	http://www.iedb.org/assay/1508215

Publication

type:	Literature
publicationVenue:	J Mol Biol
dates:	2003

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Clasien J Oomen Peter Hoogerhout Alexandre M J J Bonvin Betsy Kuipers Humphrey Brugghe Hans Timmermans Simon R Haseley Loek van Alphen Piet Gros

Data Type

method:	biological activity

Study

name:	Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations.
description:	This cyclic peptide was synthesized to mimic the crystallographically observed beta-hairpin conformation that region KDTNNNL adopts in the native PorA protein. D-Cysteine was chosen for for the contra-turn, because D-amino acids are known to stabilize a reverse turn. Similar requirements led to the choice of a glycine as an additional residue in the contra-turn. Bactericidal titers were tested as described in Hoogerhout et al, 1995, Infect. Immun. 63, 3473–3478 [PMID: 7543883].

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.