Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.

Title:

Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.

Dataset

identifier:	1505535
description:	epitope description:ASGQ antigen name:Major outer membrane protein P.IA host organism:Mus musculus BALB/c antibody name:MN14C11.6
aggregation:	instance of dataset
availability:	available
primaryPublications:	11273739

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006590
landingPage:	http://www.iedb.org/assay/1505535

Publication

type:	Literature
publicationVenue:	Microb Pathog
dates:	2001

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis serogroup B H44/76

Person

fullName:	M Toropainen L Saarinen P van der Ley B Kuipers H Kä yhty

Data Type

method:	ELISA

Study

name:	Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.
description:	This peptide is located in the predicted loop 1 of variable region 1 (VR1) and is part of the P1.7 epitopic determinant. The meningococcal reference strain H44/76 with B:15:P1.7,16 phenotype has the epitopes for the subtype P1.7 and P1.16 specific monoclonal antibodies in the VR1 and VR2, respectively. The reference strain H44/76, as well as three isogenic strains derived from it that differ at the P1.16 epitope but have identical P1.7 sequences are recognized equally well by this P1.7 specific monoclonal antibody.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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