Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1006590 |
| landingPage: |
http://www.iedb.org/assay/1505654 |
| type: |
Literature
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| publicationVenue: |
Microb Pathog
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| dates: |
2001
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| study type: | b cell assays |
| subject species: | Neisseria meningitidis serogroup B H44/76 |
| fullName: |
M Toropainen
L Saarinen
P van der Ley
B Kuipers
H Kä
yhty
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| method: |
ELISA
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| name: |
Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.
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| description: |
This peptide is located in the variable region 2 (VR2) at the apex of the loop 4, and is part of the P1.16 epitopic determinant. The meningococcal reference strain H44/76 with B:15:P1.7,16 phenotype has the epitopes for the subtype P1.7 and P1.16 specific monoclonal antibodies in the VR1 and VR2, respectively.
The reference strain H44/76 and an isogenic strain derived from it that harbors a single residue deletion outside the epitope were equally well recognized by the epitope-specific antibody. Similar recognition is seen to a strain that differ at the epitope (D at position 2 mutated to N), whereas replacement by H abolished reactivity.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
