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Title: Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein.
identifier: 1507662
description:
epitope description:IPKDRRSTGKSWGKPGY
antigen name:Genome polyprotein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 1383117
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1012763
landingPage: http://www.iedb.org/assay/1507662
type:
Literature
publicationVenue:
Hepatology
dates:
1992
study type: b cell assays
subject species: Hepatitis C virus isolate HC-J6
fullName:
A Machida
H Ohnuma
F
E Munekata
Y Akahane
H Okamoto
S Mishiro
method:
ELISA
name:
Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein.
description:
The peptide is conserved in other isolates,such as HC-J5, HC-J8 and HC-J7, of HCV.
To determine the residues important for binding, inhibition ELISAs were performed where the epitope-specific responses from three donors were competed with peptides with residue substitutions (for the corresponding residue in the genotype 1 sequence). Substitutions of G77 and K78 abolished the binding capacity.

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