Synthetic peptides as functional mimics of a viral discontinuous antigenic site. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptides as functional mimics of a viral discontinuous antigenic site.

Dataset

identifier:	1510206
description:	epitope description:PSQNFGHMHKVVLPPPPPPPPPPCFLMFENVPY + OX(C24) host organism:Bos taurus antibody name:anti-D8
aggregation:	instance of dataset
availability:	available
primaryPublications:	11851326

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011684
landingPage:	http://www.iedb.org/assay/1510206

Publication

type:	Literature
publicationVenue:	Biologicals
dates:	2001

Dimension

study type:	b cell assays
subject species:

Person

fullName:	J Villé n E Borrà s W M Schaaper R H Meloen M Dá vila E Domingo E Giralt D Andreu

Data Type

method:	cross blocking

Study

name:	Synthetic peptides as functional mimics of a viral discontinuous antigenic site.
description:	The epitope was designed to mimic discontinuous antigenic site D of FMDV isolate C-S8c1, which encompasses residues from VP1 (Thr193), VP2 (Ser72, Asn74, His79 in the sequence PSQNFGHMHKVVLP), and VP3 (Glu58 in the sequence FLMFENVPY). The epitope D8A, which represents the VP2 and VP3 peptides linked by a polyproline spacer, was disulfide bonded to peptide D8B (CPPPPTG), which mimics the VP1 peptide. The binding of epitope-reactive anti-D8 sera to FMDV was inhibited by FMDV site D-specific mAbs 5C4 and 2A12, demonstrating the specificity of the anti-D8 sera.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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