Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1511861 |
| description: |
epitope description:V: F43, Y47; W: Y71, K74, Q105, I106, M107, R108, I109, K110, H112, Q113, G114, Q115, H116, I117, G118, E119, M120
antigen name:Vascular endothelial growth factor A (UniProt:P15692)
host organism:Mus musculus BALB/c
antibody name:Fab 12 (humanized mAb A4.6.1)
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
9753694 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/311 |
| landingPage: |
http://www.iedb.org/assay/1511861 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
1998
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| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Y A Muller
Y Chen
H W Christinger
B Li
B C Cunningham
H B Lowman
A M de Vos
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| method: |
x-ray crystallography
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| name: |
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
|
| description: |
The epitope is composed of residues located in both chains of the VEGF homodimer.
The epitope of Fab 12 on VEGF was determined from the crystal structure of the complex, solved by molecular replacement. The asymmetric unit contains one VEGF binding domain homodimer and two Fab fragments bound to the symmetrical poles of the VEGF dimer. The authors believe that presence of the sulfate is a crystallization artifact.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
