Structure-function analyses of diphtheria toxin by use of monoclonal antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Structure-function analyses of diphtheria toxin by use of monoclonal antibodies.

Dataset

identifier:	1512451
description:	epitope description:GVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS antigen name:Diphtheria toxin (UniProt:H2GU79) host organism:Mus musculus BALB/c antibody name:43A4
aggregation:	instance of dataset
availability:	available
primaryPublications:	7679377

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1010306
landingPage:	http://www.iedb.org/assay/1512451

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	1993

Dimension

study type:	b cell assays
subject species:	Corynebacterium diphtheriae

Person

fullName:	J M Rolf L Eidels

Data Type

method:	western blot

Study

name:	Structure-function analyses of diphtheria toxin by use of monoclonal antibodies.
description:	The epitope sequence is from the reference cited: Greenfield et al. (1983) Proc. Natl. Acad. Sci. U.S.A. 80: 6853-6857 [PMID: 6316330]. The epitope recognized by mAb 43A4 was determined based on its reactivity with overlapping fragments of diphtheria toxin. MAb 43A4 recognized the epitope which contains the diphtheria toxin receptor-binding site. A study published elsewhere determined the epitope to be within residues 506-514.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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