Epitope analysis using kinetic measurements of antibody binding to synthetic peptides presenting single amino acid substitutions.

Title:

Epitope analysis using kinetic measurements of antibody binding to synthetic peptides presenting single amino acid substitutions.

identifier:	1512823
description:	epitope description:INNLIVELIRGT antigen name:Capsid protein host organism:Mus musculus BALB/c antibody name:a4x5
aggregation:	instance of dataset
availability:	available
primaryPublications:	7508237

study type:	b cell assays
subject species:	Tobacco mosaic virus

fullName:	G Zeder-Lutz D Altschuh S Denery-Papini J P Briand G Tribbick M H Van Regenmortel

method:	surface plasmon resonance (SPR)

name:	Epitope analysis using kinetic measurements of antibody binding to synthetic peptides presenting single amino acid substitutions.
description:	The kinetic rate constants were determined for the mAb binding to the epitope lacking the two C-terminal amino acids. The association rate constant (ka) was about 2-fold higher, but the dissociation rate constant (kd) was about 13 times higher and the equilibrium affinity constant (Ka) was 7-fold lower.

name:	iedb
homePage:	http://www.iedb.org

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