Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.

Dataset

identifier:	1549477
description:	epitope description:P200 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:1F1
aggregation:	instance of dataset
availability:	available
primaryPublications:	18716625

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013152
landingPage:	http://www.iedb.org/assay/1549477

Publication

type:	Literature
publicationVenue:	Nature
dates:	2008

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/South Carolina/1/1918(H1N1))

Person

fullName:	Xiaocong Yu Tshidi Tsibane Patricia A McGraw Frances S House Christopher J Keefer Mark D Hicar Terrence M Tumpey Claudia Pappas Lucy A Perrone Osvaldo Martinez James Stevens Ian A Wilson Patricia V Aguilar Eric L Altschuler Christopher F Basler James E Crowe Jr

Data Type

method:	ELISA

Study

name:	Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.
description:	This residue is located at the antigenic region Sb. Two epitope-specific mAbs (1F1 and 1I20) were tested for recognition of HA from a series of representative twentieth century H1N1 viruses. MAb 1F1 bound weakly to HA from A/Weiss/43 and A/USSR/92/77, while none recognized HA from A/FM/1/47 and A/New Caledonia/20/99. The residue at position 200 is Ser in all these virus isolates except for A/New Caledonia/20/99 where the epitope is conserved (P200). MAb 1I20 light chain isotype is kappa.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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