Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.

Dataset

identifier:	1551141
description:	epitope description:K180 antigen name:Hemagglutinin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	18716625

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013152
landingPage:	http://www.iedb.org/assay/1551141

Publication

type:	Literature
publicationVenue:	Nature
dates:	2008

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/South Carolina/1/1918(H1N1))

Person

fullName:	Xiaocong Yu Tshidi Tsibane Patricia A McGraw Frances S House Christopher J Keefer Mark D Hicar Terrence M Tumpey Claudia Pappas Lucy A Perrone Osvaldo Martinez James Stevens Ian A Wilson Patricia V Aguilar Eric L Altschuler Christopher F Basler James E Crowe Jr

Data Type

method:	in vivo assay

Study

name:	Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.
description:	This residue is located at the antigenic region Sa. It was involved in the binding of a mAb from a 1918 Influenza pandemic survivor by analysis of escape mutants of the related virus Sw/30 after incubation with the mAb. MIce were infected intranasally with five LD50 of 1918 reconstituted virus. Doses of 200 μg of mAb administered 24 hs later provided significant protection, with no mortality and significantly reduced weight loss and virus titers in the lungs.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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