Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1013417 |
| landingPage: |
http://www.iedb.org/assay/1553482 |
| type: |
Literature
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| publicationVenue: |
Clin Vaccine Immunol
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| dates: |
2008
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| study type: | b cell assays |
| subject species: |
| fullName: |
Kausik Datta
Andrew Lees
Liise-anne Pirofski
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| method: |
in vivo assay
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| name: |
Therapeutic efficacy of a conjugate vaccine containing a peptide mimotope of cryptococcal capsular polysaccharide glucuronoxylomannan.
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| description: |
The epitope was selected from a random peptide phage display library by screening with a glucuronoxylomannan (GXM)-specific, protective human mAb (2E9, IgM/lambda), described in the reference Fleuridor et al, J Immunol. 2001 166(2):1087 [PMID:11145689].
Survival was determined and serum samples were collected at a various post-vaccination time points. Chronically or acutely infected mice had longer survival than controls. In the chronic model also lower serum GXM levels at early post-vaccination times was recorded, but not at later points. A similar trend was also observed when peptide was conjugated to the diphtheria toxin (DT). The effects of vaccination on the cytokine production was attributed to the carrier protein conjugate.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
