Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein.

Title:

Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein.

Dataset

identifier:	1556625
description:	epitope description:G186, K187 antigen name:Other Neisseria meningitidis protein host organism:Mus musculus CD1 antibody name:JAR 3, JAR 5
aggregation:	instance of dataset
availability:	available
primaryPublications:	18591239

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013412
landingPage:	http://www.iedb.org/assay/1556625

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2008

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis MC58

Person

fullName:	Peter T Beernink Jo Anne Welsch Michal Bar-Lev Oliver Koeberling Maurizio Comanducci Dan M Granoff

Data Type

method:	biological activity

Study

name:	Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein.
description:	This strain expresses a fHBP of the v.1 group. The epitope-specific mAbs were not bactericidal when tested individually. However, they were bactericidal when combined with a second anti-fHbp mAb. JAR 5 antibody heavy chain isotype is IgG2b.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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