Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.

Title:

Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.

Dataset

identifier:	1557460
description:	epitope description:CKGKIQALCENPEWA antigen name:Hemagglutinin glycoprotein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	10675410

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008090
landingPage:	http://www.iedb.org/assay/1557460

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2000

Dimension

study type:	b cell assays
subject species:	Measles virus strain Edmonston

Person

fullName:	K C El Kasmi S Fillon D M Theisen H Hartter N H Brons C P Muller

Data Type

method:	ELISA

Study

name:	Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.
description:	This peptide is conserved in clade A, B3, C2, D3 and D5 measles viruses. The animals developed anti-epitope antibodies. Similar results were obtained when the immunogen was the epitope, with two linked copies of the peptide Bccc, or with two other T cell epitopes conjugates. The authors conclude that the immunogenic peptide Bccc contains a T cell epitope as well as a B cell epitope. Moreover, the response was not affected by preexisting anti-MV neutralizing antibodies, suggesting it could be used in the presence of anti-MV maternal antibodies.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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