Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.

Title:

Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.

Dataset

identifier:	1557464
description:	epitope description:ETCFQQACKGKIQALCENPEWA antigen name:Hemagglutinin glycoprotein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	10675410

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008090
landingPage:	http://www.iedb.org/assay/1557464

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2000

Dimension

study type:	b cell assays
subject species:	Measles virus strain Edmonston

Person

fullName:	K C El Kasmi S Fillon D M Theisen H Hartter N H Brons C P Muller

Data Type

method:	flow cytometry

Study

name:	Neutralization of measles virus wild-type isolates after immunization with a synthetic peptide vaccine which is not recognized by neutralizing passive antibodies.
description:	This peptide is conserved in clade A, B3, C2, D3 and D5 measles viruses. Epitope-immunized animals developed anti-virus antibodies. Two linked copies of the epitope enhanced the response. Similar but lower results are obtained when a single copy of the epitope was linked to other T cell epitope conjugates. By alanine-scanning, it was shown that the generation of anti-virus antibodies requires the Cys at position 16 and one of the other two Cys residues present.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.