Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses.

Title:

Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses.

Dataset

identifier:	1581171
description:	epitope description:N29, K33, E46, P109 antigen name:Bet v 1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15470071

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013372
landingPage:	http://www.iedb.org/assay/1581171

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	Betula pendula

Person

fullName:	Jens Holm Michael Gajhede Mercedes Ferreras Anette Henriksen Henrik Ipsen Jø rgen N Larsen Lise Lund Henrik Jacobi Anders Millner Peter A Wü rtzen Michael D Spangfort

Data Type

method:	antigen inhibition

Study

name:	Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses.
description:	Binding of allergic patients' serum IgE to Bet v 1 could be inhibited by Bet v 1 but less so by the protein when the epitopic residues mutated, suggesting the role of these residues as part of the allergy-inducing determinant.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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