Epitope mapping and functional characterization of monoclonal antibodies specific for the alpha subunit of Escherichia coli RNA polymerase.

Title:

Epitope mapping and functional characterization of monoclonal antibodies specific for the alpha subunit of Escherichia coli RNA polymerase.

identifier:	1587799
description:	epitope description:ARVEQRTDLDKLVIEMETNGT antigen name:DNA-directed RNA polymerase subunit alpha host organism:Mus musculus SJL antibody name:121C5
aggregation:	instance of dataset
availability:	available
primaryPublications:	7522231

study type:	b cell assays
subject species:	Escherichia coli

fullName:	K A Sharif N Fujita R Jin K Igarashi A Ishihama J S Krakow

method:	biological activity

name:	Epitope mapping and functional characterization of monoclonal antibodies specific for the alpha subunit of Escherichia coli RNA polymerase.
description:	The sequence source was obtained through cited reference: Igarashi et al. Nucleic Acids Res 1990 18:5945-5948 [PMID 2235479]. The epitope-specific mAb 121C5 was capable of inhibiting RNA polymerase activity as shown by a decrease or complete absence of transcription from the CRP-dependent lac and gal promoters.

name:	iedb
homePage:	http://www.iedb.org

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