Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen.

Title:

Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen.

Dataset

identifier:	1584803
description:	epitope description:S112 antigen name:Mal d 1 host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	10502033

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005128
landingPage:	http://www.iedb.org/assay/1584803

Publication

type:	Literature
publicationVenue:	Eur J Nutr
dates:	1999

Dimension

study type:	b cell assays
subject species:	Malus domestica

Person

fullName:	D Y Son S Scheurer A Hoffmann D Haustein S Vieths

Data Type

method:	biological activity

Study

name:	Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen.
description:	Residue Ser111was demonstrated to be important for serum IgE binding to Mal d 1 in a murine model of the type I allergic reaction. Mutation of Ser111 to Pro or Cys in Mad d 1 reduced the release of beta-hexosaminidase activity from RBL-2H3 cells passively sensitized with mouse IgE specific for birch pollen extract and challenged with Mad d 1 isoallergens.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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