Cross-reactive and serotype-specific antibodies against foot-and-mouth disease virus generated by different regions of the same synthetic peptide.

Title:

Cross-reactive and serotype-specific antibodies against foot-and-mouth disease virus generated by different regions of the same synthetic peptide.

Dataset

identifier:	1585476
description:	epitope description:CCRHKQKIVAPVKQTLPPSVPNLRGDLQVLAQKVARTPCG host organism:Cavia porcellus Duncan-Hartley
aggregation:	instance of dataset
availability:	available
primaryPublications:	1372368

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008932
landingPage:	http://www.iedb.org/assay/1585476

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1992

Dimension

study type:	b cell assays
subject species:

Person

fullName:	T R Doel C M Doel R F Staple R DiMarchi

Data Type

method:	in vivo assay

Study

name:	Cross-reactive and serotype-specific antibodies against foot-and-mouth disease virus generated by different regions of the same synthetic peptide.
description:	The epitope is a construct of FMDV type O1K VP1 residues 200-213 (RHKQKIVAPVKQTL) linked to residues 141-158 (VPNLRGDLQVLAQKVART). Half of the animals immunized with the O 200-O 141 vaccine constructed from FMDV type O1 sequences were protected from challenge with FMDV O1 BFS virus. Combining all doses tested, 10 of 20 animals were protected. At higher doses, 3 of 5 animals were protected.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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