Two mechanisms of antigenic diversification of foot-and-mouth disease virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Two mechanisms of antigenic diversification of foot-and-mouth disease virus.

Dataset

identifier:	1594104
description:	epitope description:TGVRRGDLAHLAAA antigen name:Polyprotein host organism:Mus musculus antibody name:7CA11, 7JD1, 7FC12, 7AH1, 7EE6, 7AB5
aggregation:	instance of dataset
availability:	available
primaryPublications:	1653494

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1009131
landingPage:	http://www.iedb.org/assay/1594104

Publication

type:	Literature
publicationVenue:	Virology
dates:	1991

Dimension

study type:	b cell assays
subject species:	Foot-and-mouth disease virus (strain C3 Indaial)

Person

fullName:	M A Martí nez J Herná ndez M E Piccone E L Palma E Domingo N Knowles M G Mateu

Data Type

method:	western blot

Study

name:	Two mechanisms of antigenic diversification of foot-and-mouth disease virus.
description:	Epitope-specific neutralizing mAbs 7CA11, 7JD1, 7FC12 (all IgG1), 7EE6 and 7AB5 (both IgG3), and 7AH1 recognized VP1 from most of the FMDV type C isolates from South America tested in the study. The importance of residue His at position 10 was shown by the lack of reactivity of all mAbs with FMDV C1 South American isolate C5 Argentina/69 and Philippines type C isolates 1/88 and 3/87, which have a Gln at this position. Substitution with Arg or Leu at this position also reduces binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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