Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Identification of antigenic epitopes in a surface protein antigen of Streptococcus mutans in humans. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1008774 |
| landingPage: |
http://www.iedb.org/assay/1590104 |
| type: |
Literature
|
| publicationVenue: |
Infect Immun
|
| dates: |
1994
|
| study type: | b cell assays |
| subject species: | Streptococcus mutans |
| fullName: |
K Matsushita
T Nisizawa
S Nagaoka
M Kawagoe
|
| method: |
ELISA
|
| name: |
Identification of antigenic epitopes in a surface protein antigen of Streptococcus mutans in humans.
|
| description: |
The epitope is located within the C-terminal region of the surface protein antigen gene PAc.
27/153 synthesized peptides within the N-terminal region A and the middle region of PAc showed similar positive Ab reactivity in an epitope screening assay, using serum samples from 5 patients (A-E). The HLA types of subjects A to E, respectively, were as follows: All, A33, B44, DR6(13), DR8, DR52, DQl; All, A33, B44, C7, DR2(15), DR6(13), DR52, DQl(DQ5); A24, All, B52, B7, C7, DR1, DR2(15),DQl(DQ5, DQ6); A2, A31, B48, C4, DR2(l5), DR9,DR53, DQl(DQ6); and A24, A31, B6l, BS9, Cl,C3, DR1, DR9, DR53, DQl(DQ5), DQ9. An identical epitope screen using saliva samples of patients A-E yielded similar reactivity. ELISA titers of serum antibodies, however, did not correspond with ELISA titers of saliva antibodies.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |