Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin.

Title:

Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin.

Dataset

identifier:	1595512
description:	epitope description:QQQQFLGQQQPFPPQQPY antigen name:Other Triticum aestivum (Canadian hard winter wheat) protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	9822275

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005179
landingPage:	http://www.iedb.org/assay/1595512

Publication

type:	Literature
publicationVenue:	Clin Exp Immunol
dates:	1998

Dimension

study type:	b cell assays
subject species:	Triticum aestivum

Person

fullName:	M ten Dam Y Van De Wal M L Mearin Y Kooy S Peñ a J W Drijfhout F Koning M Van Tol

Data Type

method:	ELISA

Study

name:	Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin.
description:	The minimal epitope recognized by the majority (>75%) of serum IgA from 10 children with celiac disease was determined by truncation analysis of the immunodominant peptide 23-43 (PLVQQQQFLGQQQPFPPQQPY). Greater than 50% of sera also recognized the truncated peptide LGQQQPFPPQQPY. Three dominant gliadin peptides share the repetitive motif QPFXXQXPY.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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