Antigenic structure of the hemagglutinin of H9N2 influenza viruses. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic structure of the hemagglutinin of H9N2 influenza viruses.

Dataset

identifier:	1598540
description:	epitope description:T200, N201 antigen name:Hemagglutinin host organism:Mus musculus BALB/c antibody name:E2/3, L7/7
aggregation:	instance of dataset
availability:	available
primaryPublications:	18989614

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013923
landingPage:	http://www.iedb.org/assay/1598540

Publication

type:	Literature
publicationVenue:	Arch Virol
dates:	2008

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/swine/Hong Kong/10/98(H9N2))

Person

fullName:	Masatoshi Okamatsu Yoshihiro Sakoda Noriko Kishida Norikazu Isoda Hiroshi Kida

Data Type

method:	biological activity

Study

name:	Antigenic structure of the hemagglutinin of H9N2 influenza viruses.
description:	The epitopic residue recognized by the mAbs was determined by sequencing the HA from antigenic variant viruses selected with the mAbs. Escape mutants with a Thr182Ile or Asn183Asp substitution were not recognized by the mAbs. MAbs E2/3 and L67/7 also binds influenza A/chicken/HK/G9/97, A/chicken/HK/FY20/99, A/chicken/Hb/3/98, A/silky chicken/HK/SF43/99, and A/duck/HK/Y280/97, all belonging to the Y280 lineage of H9N2 viruses. The authors conclude that mAbs E2/3 and L67/7 recognize the previously defined site II, which includes amino acids 135, 183, and 216, on the H9 HA molecule.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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