Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.

Title:

Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.

Dataset

identifier:	1598594
description:	epitope description:S137, W138, S139, Y180, N181, N182, T183 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:FLD21.140
aggregation:	instance of dataset
availability:	available
primaryPublications:	19381279

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1013926
landingPage:	http://www.iedb.org/assay/1598594

Publication

type:	Literature
publicationVenue:	PLoS Med
dates:	2009

Dimension

study type:	b cell assays
subject species:	H5N1 subtype

Person

fullName:	Surender Khurana Amorsolo L Suguitan Jr Yonaira Rivera Cameron P Simmons Antonio Lanzavecchia Federica Sallusto Jody Manischewitz Lisa R King Kanta Subbarao Hana Golding

Data Type

method:	biological activity

Study

name:	Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.
description:	FLD21.140 demonstrated broader cross-clade neutralization in vitro with very high neutralization titers against A/Vietnam/1203/2004 (clade 1) and A/Turkey/turkey/1/05 (clade 2.2), and a low neutralization titer against A/Anhui/1/05 (clade 2.3.4).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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