Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses.

Title:

Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses.

identifier:	1598879
description:	epitope description:K172, G174, S209 antigen name:Hemagglutinin host organism:Mus musculus BALB/c antibody name:S139/1
aggregation:	instance of dataset
availability:	available
primaryPublications:	19300497

study type:	b cell assays
subject species:	Influenza A virus (A/Aichi/2/1968(H3N2))

fullName:	Reiko Yoshida Manabu Igarashi Hiroichi Ozaki Noriko Kishida Daisuke Tomabechi Hiroshi Kida Kimihito Ito Ayato Takada

method:	biological activity

name:	Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses.
description:	MAb S139/1, which recognizes the epitopic residues, inhibited hemagglutination of Influenza A virus (A/Adachi/2/1957(H2N2)) and bound to the virus by ELISA. Variants of Aichi (H3) with amino acid substitutions K156Q, G158E, G158R, S193I, or S193R were not inhibited by mAb S139/1. Virus Adachi (H2) with a Thr instead of a Ser at residue 193 is recognized by the mAb, but variants with substitution T193K were not inhibited.

name:	iedb
homePage:	http://www.iedb.org

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