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Title: Monoclonal antibodies against an HLA-B27-derived peptide react with an epitope present on bacterial proteins.
identifier: 1601755
description:
epitope description:DREDLRTLLR
antigen name:HLA class I histocompatibility antigen, B-27 alpha chain
host organism:Mus musculus BALB/c
antibody name:A7E2
aggregation:
instance of dataset
availability:
available
primaryPublications: 1698856
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1013963
landingPage: http://www.iedb.org/assay/1601755
type:
Literature
publicationVenue:
J Immunol
dates:
1990
study type: b cell assays
subject species: Homo sapiens
fullName:
R B Raybourne
K M Williams
method:
antigen inhibition
name:
Monoclonal antibodies against an HLA-B27-derived peptide react with an epitope present on bacterial proteins.
description:
The anti-S. flexneri bacteria mAb A7E2 was previously shown [PMID: 2187807] to cross-react with the HLA-B27 peptide 63-83 (ETQICKAKAQTDREDLRTLLR). The epitope conjugated to BSA inhibited the binding of mAb to HLA-B27-positive human cell lines and to Shigella flexneri envelope proteins as effectively as the longer peptide (63-83)-BSA conjugate.

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