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Title: Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand.
identifier: 1601691
description:
epitope description:SPNQHTPPWMLK
host organism:Mus musculus BALB/c
antibody name:3E5
aggregation:
instance of dataset
availability:
available
primaryPublications: 18806257
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1013837
landingPage: http://www.iedb.org/assay/1601691
type:
Literature
publicationVenue:
J Biol Chem
dates:
2008
study type: b cell assays
subject species:
fullName:
Tarun K Dam
Marcela Torres
C Fred Brewer
Arturo Casadevall
method:
calorimetry
name:
Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand.
description:
Cryptococcus neoformans glucuronoxylomannan-specific mAb recognized the peptide mimotope conjugated to biotin. The Association constants of 3E5 IgG3 and its variants (IgG2a and IgG1) are different and range from 190E4(1/M) to 440E4 (1/M) for peptide P1 conjugated to biotin.

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