Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.

Title:

Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.

identifier:	1606347
description:	epitope description:ETIYNTTLKY antigen name:Envelope glycoprotein B host organism:Homo sapiens antibody name:8F9
aggregation:	instance of dataset
availability:	available
primaryPublications:	18772881

study type:	b cell assays
subject species:	Human betaherpesvirus 5

fullName:	Christy A Thomson Steve Bryson Gary R McLean A Louise Creagh Emil F Pai John W Schrader

method:	surface plasmon resonance (SPR)

name:	Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.
description:	The epitope-specific, hypermutated mAb affinity for the fragment 64-78 gB was analyzed by SPR and ITC. A similar value for KD was obtained by ITC (94 nM).

name:	iedb
homePage:	http://www.iedb.org

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