Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

Title:

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

identifier:	1607329
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Canis lupus familiaris
aggregation:	instance of dataset
availability:	available
primaryPublications:	16460841

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Elizabeth Head Edward G Barrett M Paul Murphy Pritam Das Mihaela Nistor Floyd Sarsoza Charles C Glabe Rakez Kayed Saskia Milton Vitaly Vasilevko Norton W Milgram Michael G Agadjanyan David H Cribbs Carl W Cotman

method:	in vivo assay

name:	Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.
description:	The epitope sequence is found in Morgan et al (2000) [PMID: 11140686]. Immunization with the epitope showed a non significant increase in CSF A beta 1–40 and decrease in A beta 1–42 in the brain that was not statistically significant. Immunohistochemistry in brains from immunized aged dogs showed little differences in the extent of diffuse plaque accumulation.

name:	iedb
homePage:	http://www.iedb.org

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