Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies.

Dataset

identifier:	1617184
description:	epitope description:DAEFRHDS antigen name:Amyloid beta A4 protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16130106

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008554
landingPage:	http://www.iedb.org/assay/1617184

Publication

type:	Literature
publicationVenue:	Ann Neurol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Michael Lee Frederique Bard Kelly Johnson-Wood Celeste Lee Kang Hu Sue G Griffith Ronald S Black Dale Schenk Peter Seubert

Data Type

method:	antigen inhibition

Study

name:	Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies.
description:	When polyclonal antibodies from patient's serum were immuno-depleted with A beta 1-8, they no longer bound to plaques in APP mice, which produce Amyloid beta protein precursor in their brain, showing that the epitope is essential for this binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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