A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).

Title:

A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).

identifier:	1617242
description:	epitope description:NQILKPKLISYTLPVVG antigen name:Glycoprotein G host organism:Oryctolagus cuniculus antibody name:Mab45
aggregation:	instance of dataset
availability:	available
primaryPublications:	19019819

study type:	b cell assays
subject species:	Nipah henipavirus

fullName:	Hector C Aguilar Zeynep Akyol Ataman Vanessa Aspericueta Angela Q Fang Matthew Stroud Oscar A Negrete Richard A Kammerer Benhur Lee

method:	biological activity

name:	A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).
description:	The epitope specificity of the monoclonal antibody was deduced based on binding to Nipah virus glycoprotein deletion mutants. In further assays, triple alanine scan mutants in the epitopic region none of the triple alanine mutants showed a significant decrease in Mab45 binding. The authors suggest this may indicate that the Mab45 epitope was complex and was not determined by any short primary linear sequence, or that deletion of this region may have caused conformational changes in the protein preventing epitope binding by the monoclonal antibody.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.