Conformation-dependent GAD65 autoantibodies in diabetes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Conformation-dependent GAD65 autoantibodies in diabetes.

Dataset

identifier:	1617338
description:	epitope description:VTWNPHKMMGVPLQC antigen name:Glutamate decarboxylase 2 host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	15365614

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007485
landingPage:	http://www.iedb.org/assay/1617338

Publication

type:	Literature
publicationVenue:	Diabetologia
dates:	2004

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	D Luo L K Gilliam C Greenbaum L Bekris C S Hampe T Daniels W Richter S M Marcovina O Rolandsson M Landin-Olsson I Kockum A Lernmark

Data Type

method:	immunoprecipitation

Study

name:	Conformation-dependent GAD65 autoantibodies in diabetes.
description:	The epitope sequence is from the reference cited: Karlsen et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88: 8337-8341 [PMID: 1924293]. The rabbit anti-peptide sera reacted with the wild type GAD65 and the mutated GAD65 with an E517P substitution. The region 390-404 contains the active site of the enzyme.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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