Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1013173 |
| landingPage: |
http://www.iedb.org/assay/1617830 |
| type: |
Literature
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| publicationVenue: |
Virus Res
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| dates: |
2008
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| study type: | b cell assays |
| subject species: | Sapporo rat virus |
| fullName: |
Marie Lindkvist
Jonas Nä
slund
Clas Ahlm
Gö
ran Bucht
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| method: |
ELISA
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| name: |
Cross-reactive and serospecific epitopes of nucleocapsid proteins of three hantaviruses: prospects for new diagnostic tools.
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| description: |
In 9 and 11 out of 14 nephropatia epidemica patients with cross-reactivity to the Seoul virus Sapporo SR11 Nucleocapsid protein, a significant reduction in the reactivity was seen when residues HEGQ-RQKK or DPDD were replaced by alanine, respectively. For the HEGQ and RQKK substitutions, mutants where only one of the two stretches was changed gave similar results than the 8-residue replaced mutant in most of the patients. For the DPDD replaced mutant, the ELISA results were confirmed by western blot.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
