Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1019142 |
| landingPage: |
http://www.iedb.org/assay/1795991 |
| type: |
Literature
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| publicationVenue: |
J Med Virol
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Hepatitis B virus |
| fullName: |
L Wu
J W He
X Yao
H M Li
Y M Wen
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| method: |
ELISA
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| name: |
A novel hepatitis B virus variant S 129 (Gln-->Leu): lack of correlation between antigenicity and immunogenicity.
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Leu): lack of correlation between antigenicity and immunogenicity.-->
| description: |
Mice immunized with the wild-type plasmid DNA encoding the HBsAg produced anti-HBs antibodies. Mice immunized with a construct containing a class II variant, a mutation at residue 129 (Q to L), failed to produce anti-HBs antibodies, suggesting a key role for Q129 in binding. This residue lies within the ""a"" determinant of the HBsAg and is known to be important in neutralization.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
