Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1795941 |
| description: |
epitope description:I233, D234, K235, S236, E237, G238, R239, F240, H241, V242, L266, K270
antigen name:Beta-2 adrenergic receptor
host organism:Mus musculus BALB/c
antibody name:Fab5
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
17952055 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019683 |
| landingPage: |
http://www.iedb.org/assay/1795941 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2007
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Sø
ren G F Rasmussen
Hee-Jung Choi
Daniel M Rosenbaum
Tong Sun Kobilka
Foon Sun Thian
Patricia C Edwards
Manfred Burghammer
Venkata R P Ratnala
Ruslan Sanishvili
Robert F Fischetti
Gebhard F X Schertler
William I Weis
Brian K Kobilka
|
| method: |
x-ray crystallography
|
| name: |
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
|
| description: |
The epitope of Fab5 on ß2AR365 bound to carazolol (an inverse agonist) was determined from the crystal structure of the complex, solved by molecular replacement. To improve the size and uniformity of the crystals, 48 amino acids were removed from the unstructured C terminus of the beta-2 adrenergic receptor to generate ß2AR365. This structure is identical to the structure where the cleavage site was inserted after amino acid 24 of AR365 [PDB: 2R4S].
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
