Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1795539 |
| description: |
epitope description:D-Glcp-(1->3)-[alpha-D-GlcpNAc-(1->2)]-6-PEA-L-alpha-D-Hepp-(1->3)-L-alpha-D-Hepp-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo
antigen name:lipooligosaccharide
host organism:Homo sapiens
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
18835574 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1014111 |
| landingPage: |
http://www.iedb.org/assay/1795539 |
| type: |
Literature
|
| publicationVenue: |
Vaccine
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Neisseria meningitidis MC58 |
| fullName: |
Anne Jä
kel
Joyce S Plested
J Claire Hoe
Katherine Makepeace
Margaret-Anne J Gidney
Suzanne Lacelle
Frank St Michael
Andrew D Cox
James C Richards
E Richard Moxon
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| method: |
biological activity
|
| name: |
Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.
|
| description: |
The epitope is the inner core region of LOS from N. meningitidis MC58 and other strains.
The epitope-specific IgG preparation reacts with whole cells in an opsonization assay with mutants that lack PEtn at position 3 of HepII in the inner core region of the LOS (lpt3 mutant) and the LOS lacking also the outer core (icsB-lpt3 mutant) but failed to react with the WT (MC58 strain).
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
