Prolonged survival of GalT-KO swine skin on baboons. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Prolonged survival of GalT-KO swine skin on baboons.

Dataset

identifier:	1795591
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group host organism:Papio anubis
aggregation:	instance of dataset
availability:	available
primaryPublications:	20522247

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019988
landingPage:	http://www.iedb.org/assay/1795591

Publication

type:	Literature
publicationVenue:	Xenotransplantation
dates:	2010

Dimension

study type:	b cell assays
subject species:	Sus scrofa

Person

fullName:	Joshua Weiner Kazuhiko Yamada Yoshinori Ishikawa Shannon Moran Justin Etter Akira Shimizu Rex Neal Smith David H Sachs

Data Type

method:	biological activity

Study

name:	Prolonged survival of GalT-KO swine skin on baboons.
description:	Serum of two baboons that received skin grafts showed greater antibody-mediated cytotoxicity to Gal-positive PBMC than to GalT knockout PBMC. Within the first week after transplant, the cytotoxicity was due to anti-Gal IgM as shown by loss of cytotoxicity with addition of DTT.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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