Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.

Title:

Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.

identifier:	1630721
description:	epitope description:R29, R31, K80, K85 antigen name:Bla g 4 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	19056737

study type:	b cell assays
subject species:	Blattella germanica

fullName:	Yih Wan Tan Siew Leong Chan Tan Ching Ong Le Yau Yit Yuen Sung Tiong Fook Tim Chew J Sivaraman Yu Keung Mok

method:	western blot

name:	Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
description:	Only 2 out 24 allergic patients sera (8%) showed a significant drop in IgE binding to below 80% of the reactivity of the wild type protein in a dot-blot of mutants R30A, R32A, and K81Amutants R24A, R26A and K75A, and a more minor drop was found for mutant K86A. An ELISA with serum from a selected patient also showed that these mutations did not cause significant reduction in IgE binding, indicating that these residues may not be major epitopes of Bla g 4.

name:	iedb
homePage:	http://www.iedb.org

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