Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.

Title:

Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.

identifier:	1630724
description:	epitope description:D16, D49, E80, Q105 antigen name:Other Periplaneta americana (American cockroach) protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	19056737

study type:	b cell assays
subject species:	Periplaneta americana

fullName:	Yih Wan Tan Siew Leong Chan Tan Ching Ong Le Yau Yit Yuen Sung Tiong Fook Tim Chew J Sivaraman Yu Keung Mok

method:	western blot

name:	Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
description:	About 50% of the allergic patients sera showed a significant drop in IgE binding to below 80% of the reactivity of the wild type protein in a dot-blot of single residue mutants where the epitopic residues were changed to alanine. An ELISA with serum from a selected patient also confirmed these findings, indicating that these residues are essential residues for IgE binding in Per a 4.

name:	iedb
homePage:	http://www.iedb.org

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