High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

Title:

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

identifier:	1619869
description:	epitope description:E517, E521 antigen name:Glutamate decarboxylase 2 host organism:Homo sapiens antibody name:M2 (MICA-2)
aggregation:	instance of dataset
availability:	available
primaryPublications:	10222205

study type:	b cell assays
subject species:	Homo sapiens

fullName:	H L Schwartz J M Chandonia S F Kash J Kanaani E Tunnell A Domingo F E Cohen J P Banga A M Madec W Richter S Baekkeskov

method:	immunoprecipitation

name:	High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
description:	The epitope recognized by the human mAb was deduced based on reactivity with GAD65/67 chimeric proteins and single amino acid substitutions replacing GAD65 residues with that found in GAD67. Single amino acid substitutions E517P or E521Q abolished reactivity with M2, indicating these are critical residues.

name:	iedb
homePage:	http://www.iedb.org

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