Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.

Title:

Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.

Dataset

identifier:	1620481
description:	epitope description:MCVTQYQKESQAYYDGRRSSS antigen name:Major prion protein host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	19295917

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014052
landingPage:	http://www.iedb.org/assay/1620481

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2009

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Martine Bruley Rosset Antoine Sacquin Sylvie Lecollinet Thomas Chaigneau Micheline Adam Franç ois Crespeau Marc Eloit

Data Type

method:	ELISA

Study

name:	Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.
description:	To control for the transduction procedure, the experiment was also performed using Tg650 transgenic mice, which overexpress hPrP in a Prnp-/- background. Similar results were observed.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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