An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens.

Title:

An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens.

Dataset

identifier:	1620694
description:	epitope description:KTNMKHMAGAAAAGAVVGGLG antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:P1:1
aggregation:	instance of dataset
availability:	available
primaryPublications:	18507665

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014113
landingPage:	http://www.iedb.org/assay/1620694

Publication

type:	Literature
publicationVenue:	Brain Pathol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Michael Jones Darren Wight Victoria McLoughlin Katherine Norrby James W Ironside John G Connolly Christine F Farquhar Ian R MacGregor Mark W Head

Data Type

method:	antigen inhibition

Study

name:	An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens.
description:	Pre-incubation of the epitope-specific mAb with the aggregate epitope peptide led to loss of binding, whereas pre-incubation with the monomeric form of the epitope did not block binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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