Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.

Title:

Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.

identifier:	1621146
description:	epitope description:R205 antigen name:Hemagglutinin host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	19032063

study type:	b cell assays
subject species:	Influenza A virus (A/Indonesia/5/2005(H5N1))

fullName:	Yixin Chen Kun Qin Wai Lan Wu Guoqiang Li Jun Zhang Hailian Du Mun Hon Ng J Wai-Kuo Shih J S Malik Peiris Yi Guan Honglin Chen Ningshao Xia

method:	in vivo assay

name:	Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.
description:	Mice were challenged with 10 MLD50 of either one of four representative H5N1 strains A/VNM/1194/2004, A/BH Goose/QH/15C/2005, A/IDN/5/2005, or A/SZ/406H/2006. Survival, body weight loss and viremia were significantly improved for all flu strains when mice received 20 mg/kg of the epitope-specific, H5 cross-reactive mAb at different times after infection. Full protection was observed in the groups receiving the mAb on day 1 or 2 after infection and protection was observed for some strains even when treatment was delayed to 3 days after infection. For doses as low as 5 mg/kg, protection at day 1 p.i. was complete.

name:	iedb
homePage:	http://www.iedb.org

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