Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.

Title:

Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.

Dataset

identifier:	1632469
description:	epitope description:ARDLLPAKNGEEQTVQFLLE antigen name:Glutamate decarboxylase 1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7519242

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007612
landingPage:	http://www.iedb.org/assay/1632469

Publication

type:	Literature
publicationVenue:	J Exp Med
dates:	1994

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	J Kim M Namchuk T Bugawan Q Fu M Jaffe Y Shi H J Aanstoot C W Turck H Erlich V Lennon S Baekkeskov

Data Type

method:	antigen inhibition

Study

name:	Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
description:	The epitope sequence is from the cited reference Bu et al Proc Natl Acad Sci 89, 1992 [PMID: 1549570]. The epitope failed to block the binding of sera from Stiff-Man Syndrome patients to human GAD65.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.

Related Publications

Feedback?