Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.

Title:

Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.

Dataset

identifier:	1634809
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG antigen name:Amyloid beta A4 protein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	15661919

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/423
landingPage:	http://www.iedb.org/assay/1634809

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Michael G Agadjanyan Anahit Ghochikyan Irina Petrushina Vitaly Vasilevko Nina Movsesyan Mikayel Mkrtichyan Tommy Saing David H Cribbs

Data Type

method:	immuno staining

Study

name:	Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.
description:	Mice immunized with the epitope produced antibodies that were able to bind to amyloid plaques in brain tissue from a patient with Alzheimer's disease.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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