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Title: Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens.
identifier: 1635265
description:
epitope description:VLGGGCALLRCIPALDSLTPANED
antigen name:60 kDa heat shock protein, mitochondrial (UniProt:P10809)
host organism:Mus musculus NOD
aggregation:
instance of dataset
availability:
available
primaryPublications: 9133541
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1014448
landingPage: http://www.iedb.org/assay/1635265
type:
Literature
publicationVenue:
Diabetes
dates:
1997
study type: b cell assays
subject species: Homo sapiens
fullName:
D Elias
A Meilin
V Ablamunits
O S Birk
P Carmi
S Kö
nen-Waisman
I R Cohen
method:
ELISA
name:
Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens.
description:
Treatment with the peptide induced antibodies to the epitope. The isotypes of the anti-peptide antibodies were mostly of IgG1 and IgG2b. Treatment with the peptide reduced antibodies to Hsp60, GAD65, and insulin compared with control mice.

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