Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.

Title:

Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.

Dataset

identifier:	1638082
description:	epitope description:MASPGSGFWSFGSEDGS antigen name:Glutamate decarboxylase 2 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	8904930

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014457
landingPage:	http://www.iedb.org/assay/1638082

Publication

type:	Literature
publicationVenue:	Acta Diabetol
dates:	1996

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	B Ziegler M Schlosser F Lü hder M Strebelow P Augstein W Northemann A C Powers M Ziegler

Data Type

method:	cross blocking

Study

name:	Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.
description:	The identical sequence is found in mouse, rat and human GAD65. The sequence is from the reference cited: Ziegler et al. (1994) Diabetes Res 25: 47-64 [PMID: 7544254]. The epitope was deduced. The binding of epitope-specific mAb M61/7E11 to GAD65 was displaced by 3 of 3 sera from nondiabetic patients with Stiff-man syndrome, indicating that the human sera recognized the epitope. Generation of mAb M61/7E11 is described in the reference cited: Ziegler et al. (1994) Diabetes Res 25: 47-64 [PMID: 7544254].

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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