Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model.

Dataset

identifier:	1640014
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16630540

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007106
landingPage:	http://www.iedb.org/assay/1640014

Publication

type:	Literature
publicationVenue:	Biochem Biophys Res Commun
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Ken-ichiro Fukuchi Mary Ann Accavitti-Loper Hong-Duck Kim Kazuki Tahara Yunpeng Cao Terry L Lewis Robert C Caughey Helen Kim Robert Lalonde

Data Type

method:	in vivo assay

Study

name:	Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model.
description:	The epitope-specific scFv was able to reduce amyloid deposits in the brain of passively immunized transgenic mice which developed developed Alzheimer's-like syndrome before the antibody transfer, compared to untreated mice. It was effective in clearing both diffuse and fibrillar A beta deposits.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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