Characterisation of an epitope specific to the neuron-specific isoform of human enolase recognised by a monoclonal antibody raised against a synthetic peptide corresponding to the C-terminus of beta/A4-protein.

Title:

Dataset

identifier:	1640550
description:	epitope description:KGAIIGLMVGGVVI antigen name:Amyloid beta A4 protein host organism:Mus musculus BALB/c antibody name:22.212
aggregation:	instance of dataset
availability:	available
primaryPublications:	7691181

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1010156
landingPage:	http://www.iedb.org/assay/1640550

Publication

type:	Literature
publicationVenue:	Biochim Biophys Acta
dates:	1993

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	C R Harrington G B Quinn J Hurt I N Day C M Wischik

Data Type

method:	immuno staining

Study

name:	Characterisation of an epitope specific to the neuron-specific isoform of human enolase recognised by a monoclonal antibody raised against a synthetic peptide corresponding to the C-terminus of beta/A4-protein.
description:	The epitope-specific mAbs stained the cytoplasm of neuronal cells in Alzheimer's disease. Some beta-amyloid plaques and plaque cores were strongly labeled with the epitope-specific mAb when sections had been pretreated with protease. The cytoplasmic staining with the mAb was still observed after proteolysis. There was no evidence that this mAb recognised cerebrovascular beta-amyloid deposits or neurofibrillary tangles (either intra- or extra-cellular) with or without proteolysis.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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